Search on: TUMOR SUPPRESSOR PROTEIN P53 
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Descriptor English:   Tumor Suppressor Protein p53 
Descriptor Spanish:   Proteína p53 Supresora de Tumor 
Descriptor Portuguese:   Proteína Supressora de Tumor p53 
Synonyms English:   p53 Tumor Suppressor Protein  
Tree Number:   D12.776.260.820
D12.776.624.776.775
D12.776.660.825
D12.776.744.845
Definition English:   Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. 
History Note English:   2005(1991); 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   29089 
Unique Identifier:   D016159 

Occurrence in VHL: 		 

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